In diabetes-induced cardiomyocyte senescence, the inhibition of PINK1/Parkin-induced mitophagy was reported to reduce the number of senescence-associated-β-galactosidase-positive cardiomyocytes, suggesting that restricting mitophagy can prevent senescence in cardiomyocytes (Zha et al., 2017). This evidence concerns the gene PRKN and diabetes mellitus.