HCRT and hypertensive disorder: Studies have shown that orexin system activity is increased in the hypothalamic paraventricular nucleus (PVN), and upregulated orexin system activity is implicated in several forms of hypertension, including salt-sensitive and obesity-related hypertension (Zhou et al., 2015, 2019b; Huber et al., 2017; Fan et al., 2018).