In the heart tissue of transverse aortic constriction-induced HF mice, myocardial expression of CCR2 ligand such as CCL2, CCL7, and CCL12 was enhanced, accompanied with significantly increased proinflammatory monocyte-derived CCR2+ macrophages (Xia et al., 2009; Liao et al., 2018; Patel et al., 2018). The gene discussed is CCR2; the disease is hydrops fetalis.