The prespecified subanalysis of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) showed that for patients with prior MI and elevated high-sensitivity C-reactive protein (hs-CRP), canakinumab effectively reduced HF-related hospitalization and all-cause mortality at a dose-dependent manner (Everett et al., 2019). The gene discussed is CRP; the disease is hydrops fetalis.