AGT and cardiac hypertrophy: In angiotensin II-induced HF mice model, B-cell depletion by anti-CD22 antibody resulted in reduced cardiomyocyte apoptosis, proinflammatory cytokines levels, and immunoglobulin G deposition in the myocardium; alleviated cardiac hypertrophy; and preserved left ventricular function (Cordero-Reyes et al., 2016).