OSM and familial dilated cardiomyopathy: Apart from that, a recent single-cell sequencing study indicated that in pressure overload HF mice, CCR2+M1 like proinflammatory macrophages, expressed a high level of oncostatin M (OSM) (Martini et al., 2019), which exerted a major role of cardiomyocyte dedifferentiation and remodeling during AMI and in DCM (Kubin et al., 2011).