On the other hand, leptin activates the sympathetic nervous system and increases blood pressure (Asferg et al., 2010; Shankar and Xiao, 2010; Kshatriya et al., 2011; Bell and Rahmouni, 2016; Shin et al., 2019a, 2021), predisposing to hypertension. Here, LEP is linked to Hypertension.