NOS2 and neoplasm: Finally, in NSCLC, it has been shown a correlation between iNOS levels and activation of COX-2, PGE2, and vascular endothelial growth factor (VEGF), all of them related to induction of angiogenesis and thus with tumor progression (Marrogi et al., 2000; Korde Choudhari et al., 2013) (Figure 6).