In addition, decreased expression of the sGC enzyme has been observed in alveolar and bronchial epithelial cells and in airway smooth muscle cells in COPD patients and smokers (Glynos et al., 2013; Weissmann et al., 2014), as well as in asthmatic patients and animal models of asthma (Papapetropoulos et al., 2006; London et al., 2018). Here, SGCB is linked to chronic obstructive pulmonary disease.