HIF1A and preeclampsia: In humans, elevated levels of placental HIF-1α, beyond the first trimester, are strongly associated with preeclampsia (Caniggia and Winter, 2002; Soleymanlou et al., 2005; Zamudio et al., 2007; Rolfo et al., 2010; Tal, 2012; Iriyama et al., 2015; Korkes et al., 2017; Park et al., 2018; Rana et al., 2019).