CDH1 and neoplasm: In addition, EMT inhibits E-cadherin expression, causing impaired adhesion and cell polarity during the development of epithelial tumors (carcinomas) and becomes evident at the stage of invasion (mesenchymal phenomenon), when tumor cells detach from the primary tumor and acquire the ability to cross the surrounding area (Behrens et al., 1992; Stetler-Stevenson et al., 1993; Christofori and Semb, 1999; Tepass et al., 2000; Thiery, 2002; Prieto-García et al., 2017) and this promotes formation of cancer stem cells (Mani et al., 2008; Polyak and Weinberg, 2009).