SNAI2 and neoplasm: Moreover, our data show that the TME clearly induces the expression of EMT-related transcription factors such as Slug and NF-κB, indicating targeted EMT activation, and they are known to be highly expressed especially in tumor stem cells and invaded tumor cells (Bhat-Nakshatri et al., 2010; Jang et al., 2015), and Calebin A suppressed the TME-induced expression of Slug and NF-κB.