NFKB1 and neoplasm: This finding and our previous studies are consistent with previous research demonstrating that NF-κB becomes activated in tumor cells in responding to diverse groups of pro-inflammatory substances, including cytokines and TME, and inhibits apoptosis (Baeuerle and Baichwal, 1997; Buhrmann et al., 2019; Buhrmann et al., 2020a).