Stromal cells in the TME are recognized to have a pivotal function in the stimulation of EMT in tumor cells (Guo and Deng, 2018) and TME-mediated EMT induction in tumor cells is stimulated by activating various cell signaling pathways including TNF-β, NF-κB and Wnt signaling connected with cancer progression (Jing et al., 2011). The gene discussed is LTA; the disease is neoplasm.