Overall, our data strongly indicate that, on the one hand TME promotes the formation of the NF-κB/Slug complex during tumorigenesis, resulting in malignancy and metastasis in CRC cells, and, on the other hand Calebin A prevents TME-induced EMT, partly due to blockage of the NF-κB/Slug route. Here, SNAI2 is linked to colorectal carcinoma.