Indeed, it has been previously reported that TME-induced TGF-β1 expression in CRC cells in a Smad2-dependent process (Jang et al., 2015), and it is known to play a major role in TGF-β1-induced tumor progression, migration, and EMT (Li et al., 2014). The gene discussed is TGFB1; the disease is colorectal carcinoma.