Furthermore, evodiamine regulated the activity of the p53 signaling pathway to promote the apoptosis of human CRC cells HCT116 and lower the MMP3 expression via deactivating the JAK2/STAT3 pathway by the reduction of PGI to suppress migration of cancer cells and decrease the levels of the secreted form of autocrine motility factor (AMF) (Zhao et al., 2015). Here, TP53 is linked to colorectal carcinoma.