In addition, curcumin could also retard the EMT process by regulating the TET1-NKD-Wnt signaling pathway and then reverse 5-FU resistance of colon cancer cells HCT116 (Lu et al., 2020b), as well as reinforce cisplatin resistance of colon cancer cells HCT 8 by targeting LncRNA-KCNQ1OT1 (Zheng et al., 2021). This evidence concerns the gene NKD1 and malignant colon neoplasm.