The study on the potential target, molecular mechanism, and antitumor effect of shikonin against CRC in vivo and in vitro demonstrated that it facilitated human CRC cells apoptosis and autophagy through targeting the galectin-1 and JNK signaling pathway, which delineated a promising and potential novel therapy for CRC (Zhang et al., 2020a). Here, MAPK8 is linked to colorectal carcinoma.