As IL-1β is thought to play a key role in OA development, and intra-articular injection of IL-1 receptor antagonist (IL1-Ra) has demonstrated to improve KOOS (Knee Injury and Osteoarthritis Outcome Score) in patients with anterior cruciate ligament (ACL) tear (Krauss et al., 2012), particular attention has focused on this cytokine. Here, IL1B is linked to knee injury.