Therefore, several types of RAAS blockers including angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), mineralocorticoid receptor antagonists (MRAs), and direct renin inhibitors (DRIs) have been frequently prescribed, and they are expected to prevent cardiovascular events and have reno-protective effects in patients with CKD. This evidence concerns the gene ACE and chronic kidney disease.