Paeoniflorin can regulate the local immune-inflammatory responses of liver fibrosis pathology (Chen et al., 2012), while Naringin can suppress the NF-κB signal in hepatic stellate cells to regulate the TIMP-MMP13 pathway-mediated fibrogenesis/fibrolysis balance (Anuja et al., 2018). Here, TIMP1 is linked to Hepatic fibrosis.