Beyond the recognized AD genes identified in the gene lists garnered from the GWAS and single-cell RNA-seq studies, several other genes (TREM2, CD33, CHRNA2, PRSS8, ACE, TKT, APP, and GABRA1) were found to be the targets of clinical AD drugs reported by Cummings et al. (2019). The gene discussed is PRSS8; the disease is Alzheimer disease.