PIK3R1 and Stroke: By regulating these pathways, GRb1 suppresses neuroinflammation and microglia-mediated inflammatory reactions, reduces the damage caused by inflammatory factors, improves the integrity and normal functions of the BBB, and thus inhibits necrosis and apoptosis associated with anti-inflammatory activities at the early stages after stroke, which plays a fundamental role in the maintenance of CNS homeostasis, BBB structural integrity, and normal functions of the NVU.