In this review, we found that GRb1 might alleviate cerebral/neural ischemia injury via its antiapoptotic, antioxidant, and anti-inflammatory activities, and effects on mitochondrial homeostasis, promoting neurogenesis, and improving brain functional connections and interactions, which provides more evidence for basic studies and further promotes the development of GRb1 as a candidate drug for the clinical treatment of ischemic stroke. This evidence concerns the gene PIK3R1 and ischemic stroke.