Recent data demonstrated that, different from mild-to-moderately ill patients, severely ill patients showed a highly impaired type I IFN response and elevated level of TNF-α and IL-6 (Hadjadj et al., 2020); and (C) Aging impaired and delayed the production of type I IFNs (Bajaj et al., 2020) and DS is associated with premature aging, which could be an explanation for initial findings of a higher risk of mortality of DS patients with COVID-19 at ages over 40 years (Huls et al., 2021). The gene discussed is TNF; the disease is Dravet syndrome.