IFN signaling hyperactivation in DS subjects caused by overexpression of the interferon receptors and target genes is linked with chronic immune dysregulation, which has been demonstrated by an abundance of evidence and can be characterized by being more predisposed to bacterial infection in the respiratory tracts, weaker response to antibody, and high level of autoantibodies (Ram and Chinen, 2011; Espinosa, 2020; Gensous et al., 2020). The gene discussed is IFNA1; the disease is Dravet syndrome.