Unlike non-DS AD, the brain in DS harbors triplication of many inflammation-related genes, including SOD1, S100B, and genes encoding multiple interferon receptors and several interferon target genes on Hsa21, raising the possibility that DS constitutes a unique environment for the inflammatory signals characteristic of AD neuropathology (Figure 1B; Wilcock, 2012). The gene discussed is IFNAR2; the disease is Alzheimer disease.