Although most studies have shown that CSF sTREM2 is increased in the presence of AD biomarkers, the results are somewhat inconsistent regarding sTREM2 levels in amyloid-positive (A+) and tau-positive (T+) cognitively normal (CN) individuals (Ewers et al., 2019; Suárez-Calvet et al., 2019), patients with mild cognitive impairment (MCI) (Gispert et al., 2016b; Henjum et al., 2016; Suárez-Calvet et al., 2016b, 2019; Ewers et al., 2019; Knapskog et al., 2020), and those with AD dementia (Gispert et al., 2016b; Piccio et al., 2016; Suárez-Calvet et al., 2016b, 2019). This evidence concerns the gene MAPT and Cognitive impairment.