BDNF and Alzheimer disease: EPO content (Figure 5A) in the AD+IHT mice also exceeded that of the AD+sham-IHT mice (19.3 ± 3.3), and a trend toward higher BDNF content in the AD+IHT vs. AD+sham-IHT mice (12.9 ± 1.4) was noted (Figure 5B).