BDNF and Alzheimer disease: β-actin-normalized BDNF contents (Figure 4D) in the AD+IHT mice (1.52 ± 0.14) were doubled vs. AD+sham-IHT mice (0.75 ± 0.62) and increased over 5-fold vs. pre-treated 3xTg-AD (0.28 ± 0.15).