On the other hand, EPO increased BDNF content in rat brain following embolic stroke (Wang et al., 2004) and in neurotoxin-challenged rat hippocampal neurons (Viviani et al., 2005), increased BDNF content and anti-apoptotic signaling in brains of haloperidol-challenged rats (Pillai et al., 2008), and augmented hippocampal BDNF content and preserved spatial and fear memory in aged rats (Jia et al., 2016). The gene discussed is BDNF; the disease is stroke disorder.