Although the difference in EPO contents (Figure 5A) in WT (35.1 ± 9.0) vs. 3xTg-AD mice (18.1 ± 2.9) did not attain statistical significance (P = 0.123), BDNF content (Figure 5B) was greater (P < 0.05) in the WT (13.5 ± 0.7) vs. 3xTg-AD mice (8.2 ± 1.6). Here, EPO is linked to Alzheimer disease.