MAPT and Alzheimer disease: However, it should be noted that amyloid β accumulation precedes tau hyperphosphorylation in 3xTg-AD mice (Belfiore et al., 2019); indeed, amyloid β creates the inflammatory milieu that activates the tau-phosphorylating protein kinases (Ontiveros-Torres et al., 2016; Huber et al., 2018).