Given the positive association between αSyn pathology and microglial NLRP3 inflammasome activation in experimental Parkinsonism (Gordon et al., 2018; Panicker et al., 2019), we investigated the contribution of mitochondrial oxidative stress and ERS in the αSynagg-induced NLRP3-dependent microglial activation response. Here, NLRP3 is linked to Parkinson disease.