Taken together, these results demonstrate that downregulation of PKCδ reduces the αSynagg-induced microglial activation response at least in part via amelioration of ERS and the TXNIP/NLRP3 signaling axis and the associated generation of proinflammatory cytokines in MMC microglial cells. Here, NLRP3 is linked to amelogenesis imperfecta type 1G.