Furthermore, using a mouse model of α-synucleinopathy known to recapitulate key pathological correlates of synucleinopathies, including the microglial activation response and DAergic neuropathology, we show that αSynPFF injection into the dorsal striatum resulted in pronounced PKCδ activation and ERS that was accompanied by upregulation of the NLRP3/TXNIP signaling axis in the nigra at 60 dpi, which represents an anatomically connected brain region. Here, TXNIP is linked to synucleinopathy.