NLRP3 and synucleinopathy: More interestingly, PKCδ activation correlated positively with the enhanced microglial ERS and TXNIP/NLRP3 signaling axis and was found to precede TH neuronal loss in the nigra of mice that received an intrastriatal injection of αSynPFF, implicating the interdependency between microglial PKCδ activation and induction of the TXNIP/NLRP3 signaling axis in α-synucleinopathy.