Moreover, LRP1-AS negatively regulates LRP1 expression by binding to Hmgb2 and inhibiting the Hmgb2-mediated increase in the transcriptional activity of Srebp1à toward LRP1, indicating that LRP1-AS plays a major role in negatively regulating the systemic clearance of Aβ during AD progression. The gene discussed is HMGB2; the disease is Alzheimer disease.