Knockdown of miR-134-5p increases the levels of the CREB-1 protein and CREB phosphorylation, eventually resulting in an increase in BDNF gene transcription and the rescue of the Aβ1–42-induced impairment in synaptic function in the hippocampus of AD rats (Baby et al., 2020). This evidence concerns the gene CREB1 and Alzheimer disease.