Two hallmarks have been identified in postmortem brains as main contributors to AD pathology: the neurofibrillary tangles, composed of hyperphosphorylated microtubule associated protein Tau (MAPT or Tau) and the extracellular β-amyloid (Aβ) plaques (Tiwari et al., 2019; Busche and Hyman, 2020). Here, MAPT is linked to Alzheimer disease.