HTT and Huntington disease: Similar to other previously mentioned neurodegenerative disorders, RBPs colocalize with the main driver of HD: HTT interacts with Ago2 and Staufen in processing bodies (P bodies) which contain translationally repressed mRNAs (Savas et al., 2008), and in dendritic RNA granules involved in transport and local translation (Savas et al., 2010).