Expression of “developmental” NaV1.2 channels in axons was also found in animal models of MS, i.e., in adult Shiverer mice that lack myelin (Westenbroek et al., 1992; Boiko et al., 2001), in transgenic mice overexpressing proteolipid protein that initially have normal myelination but then lose myelin (Rasband et al., 2003), and in the demyelinated optic nerve and spinal cord during EAE (Craner et al., 2003, 2004a; Herrero-Herranz et al., 2008). This evidence concerns the gene SCN2A and myeloid sarcoma.