TREK-2 downregulation in AL, a lesion type characterized by myelin breakdown and infiltration by inflammatory cells (Elkjaer et al., 2019; Frisch et al., 2020), may contribute to reduced glutamate and K+ buffering and neuronal over-excitation because TREK-2 helps maintain the membrane potential and low extracellular glutamate and K+ level during ischemia (Gnatenco et al., 2002; Rivera-Pagan et al., 2015). Here, KCNK10 is linked to ischemia.