We described the importance of uniquely dysregulated genes well-known to play a role in WM dysfunction in the MS brain (KCNA1, KCNA2, SCN2A, and SCN8A), or in experimental models of MS (KCNC3, KCNQ3, KCNK2, CACNA1C, CACNA1G, TRPV1, TRPM2, and PANX1). This evidence concerns the gene TRPM2 and myeloid sarcoma.