Experimental models do not provide clues regarding the functional role of NaV1.1 channels in MS: NaV1.1 expression was increased or unaltered in the optic nerve during EAE (Craner et al., 2003; O'Malley et al., 2009), while in the spinal cord, these channels clustered at the nodes of Ranvier and localized along the demyelinated regions (O'Malley et al., 2009). The gene discussed is SCN1A; the disease is myeloid sarcoma.