KCNT1 and leukodystrophy: Furthermore, KCNT1 is a causative gene in infants with hypomyelinating leukodystrophy showing WM alterations (Arai-Ichinoi et al., 2016), and KCNT1 mutations occur in infant epilepsy associated with delayed myelination, thin corpus callosum, and WM hyper-intensity in MRI (McTague et al., 2013; Shang et al., 2016; Borlot et al., 2020).