Kv3.3 may play a detrimental role in MS because it increases in injured WM axons during EAE progression in mice and in human MS lesions (Jukkola et al., 2017), and the deletion of Kv3.1, which forms hetero-tetramers with Kv3.3, reduced EAE severity in mice (Jukkola et al., 2017). Here, KCNC3 is linked to myeloid sarcoma.