We described the importance of uniquely dysregulated genes well-known to play a role in WM dysfunction in the MS brain (KCNA1, KCNA2, SCN2A, and SCN8A), or in experimental models of MS (KCNC3, KCNQ3, KCNK2, CACNA1C, CACNA1G, TRPV1, TRPM2, and PANX1). Here, KCNK2 is linked to myeloid sarcoma.