We described the importance of uniquely dysregulated genes well-known to play a role in WM dysfunction in the MS brain (KCNA1, KCNA2, SCN2A, and SCN8A), or in experimental models of MS (KCNC3, KCNQ3, KCNK2, CACNA1C, CACNA1G, TRPV1, TRPM2, and PANX1). The gene discussed is PANX1; the disease is myeloid sarcoma.