Interestingly, patients with severe MS progression show over-representation of single-nucleotide polymorphisms (SNPs) in the TRPV1 gene (Paltser et al., 2013) that can affect the expression and activity of the channel and cortical excitability, and modulate pain (Xu H. et al., 2007; Mori et al., 2012; Stampanoni Bassi et al., 2019). Here, TRPV1 is linked to myeloid sarcoma.