HDAC4 and amyotrophic lateral sclerosis: HDAC4 inhibitors can significantly improve the motor function of mouse models of amyotrophic lateral sclerosis (ALS; Pigna et al., 2019), but complete deletion of HDAC4 will aggravate the myopathy of ALS (Cohen et al., 2009), which may be related to the role of HDAC4 in maintaining the integrity of normal neuromuscular junctions.