SIRT1 and Duchenne muscular dystrophy: Chalkiadaki et al demonstrated that SIRT1 could increase the levels of PGC-1α, markers of oxidative metabolism and mitochondrial biogenesis, decrease expression of the atrogenes, and exhibits a fiber shift from fast-to-slow twitch in a genetic model of Duchenne muscular dystrophy (Chalkiadaki et al., 2014).