Chalkiadaki et al demonstrated that SIRT1 could increase the levels of PGC-1α, markers of oxidative metabolism and mitochondrial biogenesis, decrease expression of the atrogenes, and exhibits a fiber shift from fast-to-slow twitch in a genetic model of Duchenne muscular dystrophy (Chalkiadaki et al., 2014). This evidence concerns the gene PPARGC1A and Duchenne muscular dystrophy.