BACE1 and Alzheimer disease: A number of studies have placed the cholinergic system at the center of the AD etiopathogenesis, involving the overactivation of crucial enzymes, such as BACE1 and GSK3-β (Noh et al., 2009; Yoshiyama et al., 2010; Medeiros et al., 2011; Potter et al., 2011; Kalkman and Feuerbach, 2016; Zhang et al., 2016a).