Fruit fly AD models have been exploited to study both pathways involved in AD pathogenesis and to test several potential AD therapies, such as peptides, radiations, natural-derived compounds, and AChE inhibitors (Luo et al., 1992; Zhang et al., 2016b; Pham et al., 2018; Ali et al., 2019; Hwang et al., 2019; Kizhakke et al., 2019; Miyazaki et al., 2019; Zhong et al., 2019; Ogunsuyi et al., 2020). This evidence concerns the gene ACHE and Alzheimer disease.