CDH1 and neoplasm: In other studies [11,23], the decreased expression of adhesion molecules (such as E-cadherin, β-catenin) and the amplification of Bcl-224 were related to reduce cell-cell adhesion, loosen the surrounding structure of tumor cells and enabled them to spread far away or form peritoneal metastases, which could not be treated by radical surgery and lead to poor prognosis.