KCTD7 and epilepsy, early-onset: In F11, the proband IV-3 had early-onset epilepsy with homozygous variants in KCTD7. The second heterozygous variant observed in MEFV was identified in the WES data analysis as it was a previously reported variant known to cause autosomal dominant neutrophilic dermatosis, acute febrile (MIM# 608068).