Interestingly, a compelling study by Chackrabarty et al. has suggested that adeno-associated viral vector-mediated overexpression of IL-10 in amyloid-precursor protein (APP) mouse model of AD exacerbated amyloid pathology and cognitive impairment due to stunted phagocytic ability of microglia [23, 24]. This evidence concerns the gene APP and Cognitive impairment.