GSDMD and obesity due to melanocortin 4 receptor deficiency: For instance, HFD or methionine- and choline-deficient diet triggers the pyroptosis and GSDMD cleavage in the mouse liver, while loss-of-function of GSDMD prevents mice from nonalcoholic fatty liver disease and nonalcoholic steatohepatitis progression.17 In addition, adipose GSDMD serves as the target protein of melatonin, a well-known anti-obesity hormone.18 These global GSDMD-deficient in vivo studies imply the detrimental roles of GSDMD in metabolic diseases.