GSDMD and metabolic disease: For instance, liver-specific GSDMD-N drives cell pyroptosis and activates the processes of diet-induced hepatic steatosis and steatohepatitis in mice.17 Consistently, inhibition of adipose-specific GSDMD by melatonin alleviates the obesity-induced systemic inflammatory response.18 Hence, these findings strongly suggest that the loss of GSDMD function represents a new approach for the treatment of metabolic disorders.