An alternative way is to relate GPR35 phenotypes to the markers for endothelial (dys)function, such as flow-mediated endothelium-dependent vasodilation or the circulating endothelial microparticles in the human population.53,54 This will provide the prognostic value of GPR35 in the setting of cardiovascular and metabolic disorders. Here, GPR35 is linked to Other metabolic disease.