A previous report showed an increased BP profile in GPR35 knockout mice under anesthesia compared with the wild-type controls.20 Yet in another study, mice with GPR35 deletion showed resistance to BP elevation in Ang II (angiotensin II)–induced hypertension.22 To date, the potential mechanisms of GPR35 actions in endothelial function and BP regulation are not clear. Here, GPR35 is linked to Hypertension.