BTRC and coronary artery disorder: BTRC (also known as β-TrcP1) mediates ubiquitination and degradation of β-catenin, which plays an essential role in heart development as well as cardiac tissue homoeostasis in adults.68 Moreover, reduced DNA methylation and increased gene expression of BTRC within peripheral blood has been reported in patients with coronary artery disease.69 Thus, these findings suggest a link between maternal polyunsaturated fatty acid intake, altered epigenetic regulation of cardiovascular development in the fetus, and childhood measures of CVD risk.