BIN3 and heart failure: Several of the dmCpGs in the multivariate model have robust CVD links; cg17670421 is located within the BIN3 gene, which has been reported to play a role in cardiomyocyte homeostasis and is downregulated in cardiomyopathy, while plasma BIN1 levels have been shown to predict heart failure.54 Additionally, methylation within MLPH was found to have a strong predictive relationship with the incidence of coronary heart disease in a meta-analysis of 11 461 adults.