One of the main factors released by endothelial cells is the prothrombotic protein vWF.40, 41 Some studies have shown that patients with increased vWF levels have a higher incidence of adverse cardiovascular events including coronary artery disease, myocardial infarction, and thromosis.42, 43 In addition, animal studies have also highlighted the relationship of exocytosis and endothelia dysfunction. This evidence concerns the gene VWF and coronary artery disorder.