VWF and myocardial infarction: One of the main factors released by endothelial cells is the prothrombotic protein vWF.40, 41 Some studies have shown that patients with increased vWF levels have a higher incidence of adverse cardiovascular events including coronary artery disease, myocardial infarction, and thromosis.42, 43 In addition, animal studies have also highlighted the relationship of exocytosis and endothelia dysfunction.