VTCN1 and neoplasm: In an animal model of bladder UC, an antibody blocking B7-H4 was recently reported to enhance IFN-γ secretion by CD4 T cells and CD8 T cells, decrease tumor size, increase CD8 T cell infiltration in the bladder and decrease tumor-infiltrating regulatory T cells (Tregs), indicating that anti-B7-H4 treatment increased CD8 T cell activation as a mechanism of immune activation [33].