CD8A and neoplasm: We found the following: (1) higher expression of B7-H4 in tumor cells was associated with poorer histological differentiation, local invasion, poorer response to systemic chemotherapy and an independent prognostic factor for shorter survival; (2) in tumors with higher B7-H4 expression, higher CD8/TIA-1 expression was associated with better survival than lower CD8/TIA-1 expression.