EPHB2 and adenoma: It was of particular interest to see that the expression of OLFM4 (olfactomedin 4) and EPHB2 (EPH Receptor B2), both established intestinal stem cell markers, were strongly associated with WNT2 expressing cells (normal sample: OLFM4 P-value: 2.20E-16, 95% CI 0.010–0.017; EPHB2 P-value: 6.588E-12, 95% CI 0.0028–0.0070; adenoma sample: OLFM4 P-value: 6.99E-12, 95% CI 0.074–0.090; EPHB2 P-value: 2.2E-16, 95% CI 0.027–0.037, two-sided exact binomial test) (Fig. 4) suggesting autocrine regulation of WNT activity in the stem cells (Fig. 4).