Compatible with our hypothesis that the WNT2 up-regulation stems from the TAD breakage, causing CFTR regulatory elements to drive WNT2 expression, cells expressing both WNT2 and CFTR were enriched (normal sample, P-value: 0.0085, 95% confidence interval [CI] 0.0011–0.0042, adenoma sample, P-value: 8.65E-12, 95% CI 0.016–0.024, two-sided exact binomial test). This evidence concerns the gene WNT2 and adenoma.