As noted in the introduction, deposition of 4R tau aggregates is associated with a range of neurodegenerative disorders, such as progressive supranuclear palsy, corticobasal degeneration, FTDP-17, argyrophilic grain dementia, globular glial tauopathy, ageing-related tau astrogliopathy, others [33–36]. Here, MAPT is linked to semantic dementia.