CD22 and precursor B-cell acute lymphoblastic leukemia: On the other hand, mAb m971 was previously shown to target a membrane-proximal epitope on CD22, and a CAR-T cell using the m971 binding specificity achieved superior antileukemic effects in preclinical models of B-ALL in comparison with anti-CD22 CAR-T cells of similar affinity targeting membrane-distal regions (10).