Besides, the existence of elevated cytokines expression comprising pro‐inflammatory and regulatory cytokines such as IL‐1β, interferon (IFN)‐γ, IL‐1 receptor antagonist (RA), IL‐4, IL‐6, IL‐10, IL‐12, TNF‐α, and induced protein (IP)‐10, lead the way to periodontitis’ inflammatory process.22 The gene discussed is TNF; the disease is periodontitis.