Vu and colleagues found that METTL3 depletion in AML cells induces cell differentiation and apoptosis, coupled with reduced cell proliferation, by downregulating translation of its RNA targets such as C-MYC, BCL-2, and PTEN, and stimulating the activated AKT level (Vu et al. 2017). This evidence concerns the gene METTL3 and acute myeloid leukemia.