By contrast, in young adult-onset diabetes (DiYA), in individuals who were RBA-GADA positive, the addition of other IAbs was associated with increased frequency of early insulin treatment (21/42 [50%] vs 22/83 [26.5%], p = 0.01), but not in the older adult-onset diabetes (Action LADA). The gene discussed is INS; the disease is type 2 diabetes mellitus.