Because pathways found to be altered in the mutant FBXO32 heart from our transcriptional analysis included the ER or ER stress response, which is increasingly recognized as playing a role in many cardiomyopathies, we decided to focus our attention on the ER stress pathway and investigate its role in the cardiomyopathy due to the FBXO32 mutation. The gene discussed is FBXO32; the disease is cardiomyopathy.