The biological effects of Dex are mediated through binding to GR [20–22], and treatment with the GR inhibitor mifepristone (MedChemExpress, New Jersey, USA) could effectively inhibit the expression of GR in 4T1 cells (Fig. 2F) and reduced tumor cell migration induced by Dex in both 4T1 cells (Fig. 2G) and human breast cancer cells (Fig. 2H–J). Here, NR3C1 is linked to breast cancer.