Similar to our study, alterations in cell cycle and DNA repair-related genes, like ARID1A, BRCA1/2, TP53, CDKN2A/B, CDK4/6, CCND2 or ATM were also detected in tumor samples from ALK-positive NSCLC patients relapsing on second or third generations of TKI10,43,44. Here, CDK4 is linked to non-small cell lung carcinoma.