For RFS, tumor differentiation (HR (95%CI) 2.938 (1.161–7.433); P = 0.023), vascular invasion (HR (95%CI) 2.075 (1.271–3.390); P = 0.004), tumor non-encapsulation (HR (95%CI) 0.288 (0.177–0.467); P < 0.001), and high CTSA expression (HR (95%CI) 0.583 (0.362–0.939); P = 0.027) were independent risk factors confirmed by the Multivariate analysis (Table 4). The gene discussed is CTSA; the disease is neoplasm.