we queried the genetic alterations of CTSA in a cohort of 359 HCC patients (TCGA, Firehose Legacy) in the cBioportal database and found that queried gene is altered in 25 (7%) of queried HCC patients, including 1 case of truncating mutation, 1 case of amplification, and 23 cases of mRNA high expression. This evidence concerns the gene CTSA and hepatocellular carcinoma.