The Univariate Cox Regression analysis showed that tumor size (P = 0.033), TNM stage (P = 0.005), serum AFP level (P = 0.036), tumor differentiation (P = 0.008), vascular invasion (P = 0.048), and high expression of CTSA (P = 0.039) were risk factors affecting OS. The gene discussed is AFP; the disease is neoplasm.