Among the patients in the MOG-ON, AQP4-ON, and seronegative-ON groups who underwent brain/orbit/spinal MRI, brain lesions that met the McDonald criteria for MS were observed in 24.56%, 11.22%, and 21.60% of patients, respectively (p > 0.05).The percentage of patients with spinal cord lesions was high in the AQP4-ON group (29.59%, p < 0.001). This evidence concerns the gene AQP4 and myeloid sarcoma.