After clustering (Fig. 5b) and enrichment analysis of DEPs (Fig. 5c–e, and Table S4), it was found that DEPs were mainly distributed in the immune system, including primary immunodeficiency, intestinal immune network for IgA production, FcγR-mediated phagocytosis, natural killer cell-mediated cytotoxicity, the B cell receptor signaling pathway, and the FcεRI signaling pathway. The gene discussed is FCGR2A; the disease is inborn error of immunity.