We found a nominal association of rs1048943/CYP1A1 with lung Adenocarcinoma (ADC) among smokers in the dominant (GG + GA vs AA: OR = 1.99; 95% CI = 1.10–3.63; p = 0.024) effect model (Supplementary Information, Table S5). This evidence concerns the gene CYP1A1 and AIDS dementia complex.