The association of variants with different histological subtypes of lung cancer revealed del1/GSTT1 to be associated with lung adenocarcinoma, rs4646903/CYP1A1 with lung squamous cell carcinoma while rs1048943/CYP1A1 with both lung adenocarcinoma and lung squamous cell carcinoma. The gene discussed is CYP1A1; the disease is squamous cell lung carcinoma.