To explore the role GADD45a and GADD45b in psoriasis, we first analyzed the expression of GADD45a and GADD45b genes in lesional and non-lesional skin samples from 30 patients (17 male/13 female) with plaque psoriasis and 15 control subjects (7 male/8 female). This evidence concerns the gene GADD45A and psoriasis vulgaris.