The opposing effects of GADD45a and GADD45b molecules on T cell activation may counterbalance and account for the observed phenotype; the inhibitory effect of GADD45a on p38 activation seems to be overcome by the upregulated expression of GADD45b in psoriasis patients not only in unstimulated T cells but also following activation with IL-12 plus IL-18 cytokines. This evidence concerns the gene GADD45B and psoriasis.