From RNA-sequencing data of normal skin and cutaneous squamous cell carcinoma, expression of KNSTRN begins downstream of the mutation site (Supplementary Fig. 5c), implying that the mutation affects the promoter of KNSTRN. Promoter mutations are ubiquitous in sun-exposed cancers42,43 because transcription factors at the promoter can bend DNA in ways that render their binding elements vulnerable to mutagenesis by UV radiation44. The gene discussed is KNSTRN; the disease is cutaneous squamous cell carcinoma.