Moreover, FAT1, ARID2, CASP8, CREBBP, AJUBA, PTEN, PIK3CA, EZH2, KRAS, CCND1, and MTOR were nominated in 1–3 studies each as well as by us, lending credibility to their pathogenic roles in cutaneous squamous cell carcinoma. The gene discussed is PTEN; the disease is cutaneous squamous cell carcinoma.