We next investigated the regulatory mechanism of TP63 on SREBF1 transcription in SCC, focusing on ESCC model because compared with HNSC and LUSC, ESCC not only showed the highest expression of SREBF1 (Supplementary Fig. 2e), but also had the highest tumor/normal ratio (that is, the greatest upregulation in tumors; Supplementary Fig. 2d). Here, TP63 is linked to neoplasm.