In agreement with this, the treatment of animals bearing H1944 xenograft tumours with GCs led to a decrease in Ki67 immunostaining and retinoblastoma (Rb) phosphorylation (Fig. 2e; no changes in total Rb levels (Supplementary Fig. 3i)), without induction of p21 expression and apoptosis (Supplementary Fig. 3i), as seen by the absence of cleaved Caspase-3 signal. This evidence concerns the gene CASP3 and neoplasm.