At day 7 post-transplantation, we inoculated MC38-OVA tumour cells into the recipient mice subcutaneously (Fig. 6a) and observed drastically delayed tumour growth in the Sirt3 K223R TM cell-transplanted mice compared with that in the Sirt3 WT TM cell-transplanted mice (Fig. 6b, c). The gene discussed is SIRT3; the disease is neoplasm.