It consists of three members, USP26, USP29 and USP37, of which USP26 is a positive regulator of Androgen Receptor in prostate cancer cells [15], USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer [16], and USP29 has been recognized as a regulator of the checkpoint adaptor Claspin [17]. Here, USP29 is linked to Familial prostate cancer.