FCGR3A and neoplasm: Overall, mAb-redirected CIK cells showed a strong improvement in lytic activity that was always more pronounced with OBI, consistently with the higher affinity for CD16a of its glycoengineered Fc domain.34 These results found a strong confirmation in vivo in an aggressive PDX model derived from a refractory/relapsed patient, where the CIK +OBI combination restrained tumor growth favoring the immune infiltrate, and prolonged survival.